Modified Caffeine Release System and Its Immunomodulatory Effects on Breast Tumor Cells and Blood Phagocytes

Caffeine is an alkaloid present in a wide variety of plants. Currently the most consumed psychostimulant worldwide, its consumption associated with several health benefits, including modulation innate and adaptive immune response, reduction oxidative cellular stress, decreased incidence some cancers, breast cancer. Breast cancer common cause among women second leading death worldwide. The interaction between biomaterials drugs has enabled great advance science for developing controlled drug delivery systems been used to treat numerous pathologies. This work aimed evaluate immunomodulatory effects caffeine or not polyethylene glycol adsorbed microemulsion (MLP) on MCF-7 cells, phagocytic cells (MN), coculture. For biological assays, ATCC (American Type Culture Collection, USA) cell lines adenocarcinoma (MCF-7) phagocytes (MN) obtained from voluntary donors were used. (MN MCF-7) coculture treated MLP incubated rheological characterization analyses: flow curve viscosity, stress: superoxide anion assay (), activity enzyme dismutase (Cu-Zn-SOD). increased viscosity blood affected immunomodulation stress metabolism MN MLP. These data suggest that MLP-induced demonstrating antitumor via can be complementary alternative treating